Diffusion Tensor Imaging Detects Abnormalities in the Corticospinal Tract of the Brain in Patients with Adrenomyeloneuropathy
نویسندگان
چکیده
A. Gifford, A. Binstock, J. Wang, K. Zackowski, J. Farrell, P. C. van Zijl, G. Raymond, and S. Smith Department of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD, United States, University of Maryland School of Medicine, Baltimore, MD, Motion Analysis Laboratory, Kennedy Krieger Institute, Baltimore, MD, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, Vanderbilt University Institute of Imaging Science, United States, Department of Radiology, Vanderbilt University, Nashville, TN
منابع مشابه
Quantitative MRI of the spinal cord and brain in adrenomyeloneuropathy: in vivo assessment of structural changes.
Adrenomyeloneuropathy is the late-onset form of X-linked adrenoleukodystrophy, and is considered the most frequent metabolic hereditary spastic paraplegia. In adrenomyeloneuropathy the spinal cord is the main site of pathology. Differently from quantitative magnetic resonance imaging of the brain, little is known about the feasibility and utility of advanced neuroimaging in quantifying the spin...
متن کاملDiffusion Tensor Imaging Evaluation of Corticospinal Tract Hyperintensity in Upper Motor Neuron-Predominant ALS Patients
Amyotrophic lateral sclerosis (ALS) patients with predominant upper motor neuron (UMN) signs occasionally have hyperintensity of corticospinal tract (CST) on T2- and proton-density-(PD-) weighted brain images. Diffusion tensor imaging (DTI) was used to assess whether diffusion parameters along intracranial CST differ in presence or absence of hyperintensity and correspond to UMN dysfunction. DT...
متن کاملDifferentiation of Edematous, Tumoral and Normal Areas of Brain Using Diffusion Tensor and Neurite Orientation Dispersion and Density Imaging
Background: Presurigical planning for glioma tumor resection and radiotherapy treatment require proper delineation of tumoral and peritumoral areas of brain. Diffusion tensor imaging (DTI) is the most common mathematical model applied for diffusion weighted MRI data. Neurite orientation dispersion and density imaging (NODDI) is another mathematical model for DWI data modeling.Objective: We stud...
متن کاملFiber Tractography and Diffusion Tensor Imaging in Children with Agenesis and Dysgenesis of Corpus Callosum: A Clinico-Radiological Correlation
Background Corpus callosum is the largest commissure in human brain. It consists of tightly packed white matter tracts connecting the two cerebral hemispheres. In this study we aimed to evaluate role of fiber tractography (FT), and diffusion tensor imaging (DTI) in ped...
متن کاملThe topography of brain microstructural damage in amyotrophic lateral sclerosis assessed using diffusion tensor MR imaging.
BACKGROUND AND PURPOSE ALS leads to macrostructural (ie, cortical atrophy and hyperintensities along the corticospinal tract) and microstructural (ie, gray matter intrinsic damage) central nervous system abnormalities. We used a multimodal voxelwise imaging approach to assess microstructural changes independent of macrostructural volume loss in patients with ALS compared with HCs. MATERIALS A...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2009